Welcome to the White8 trial website
BACKGROUND
Fragility hip fractures present a significant global challenge to patients, clinicians and healthcare systems. The global literature confirms an overall mortality risk in the range 10-40% in the first year with much of this attributed to post-operative complications.
Surgical site infection (SSI) is a significant complication with literature for hemiarthroplasty infection stating rates as high as 7.3%. Therefore, the prevention of postoperative complications is likely to be one good way of reducing mortality in this group of patients.
Perioperative antibiotics are one proven means of reducing postoperative infection in patients undergoing hip arthroplasty for any indication. The current standard for cemented hip hemiarthroplasty is the use of parenteral antibiotics in combination with antibiotic loaded cement.
TRIAL DESIGN
This will be multi centre, multi-surgeon, parallel, two arm, randomised controlled trial. This will be embedded in the World Hip Trauma Evaluation (WHITE) comprehensive cohort.
All adult patients 60 years of age and over presenting at the trial centres, who in the opinion of the treating surgeon require acute surgical treatment with a cemented hip hemiarthroplasty are eligible for inclusion.
AIM
The aim of this pragmatic randomised controlled trial is to determine the rate of deep infection in patients treated with either low dose single antibiotic loaded cement or high dose dual antibiotic loaded cement for the treatment of hip fracture with a hemi-arthroplasty.
This study is sponsored by the Northumbria Heathcare NHS Foundation Trust, and is funded by Heraeus Medical. The trial is managed by Oxford Trauma, at the University of Oxford.
22 April 2021
Welcome back to the University Hospital Coventry research team, who have restarted recruitment to the WHiTE 8 COPAL study today!
13 April 2021
Another site has restarted recruitment to the WHiTE 8 trial yesterday, 12 April: Welcome back to the Royal Sussex County Hospital team!
8 April 2021
April's WHiTE 8 newsletter has been published and the updates are available for you to read at this link.
6 April 2021
Congratulations again to the Royal Cornwall Hospital team, who maintained their stellar form in March and topped the recruitment list with 22 new patients randomised into WHiTE 8!
19 March 2021
Welcome back to the team at Queen's Medical Centre (Nottingham University Hospitals)! They restarted recruitment to WHiTE 8 COPAL on 15 March.
16 March 2021
Welcome back on board to the Ipswich Hospital team and the Royal Berkshire Hospital team, who yesterday restarted recruitment to the WHiTE 8 trial!
09 March 2021
The WHiTE 8 newsletter for the month of March is now out and you can read it at this link.
04 March 2021
Congratulations to the Royal Cornwall Hospital team, who were top recruiters in February, with 23 patients randomised!
24 February 2021
A warm welcome back to the Southmead Hospital Bristol team, who have restarted recruitment to WHiTE 8 on 19 February. Congratulations on the first two newly recruited participants!
11 February 2021
The WHiTE 8 - COPAL newsletter for February is out! You can read it by clicking this link.
05 February 2021
Congratulations to the Royal Cornwall Hospital team, who were top recruiters for WHiTE 8 in January 2021, with 17 patients randomised!
15 January 2021
The January 2021 edition of newsletter is ready for all site teams to read.
15 January 2021
James Cook Hospital team were top recruiters for the WHiTE8 Copal trial in December 2020.Site team has recruited 21 patients.
08 January 2021
144 patients were recruited in December 2020. Thank you to all site teams for amazing work.s to all of our participating sites!
