Fragility hip fractures present a significant global challenge to patients, clinicians and healthcare systems. The global literature confirms an overall mortality risk in the range 10-40% in the first year with much of this attributed to post-operative complications.
Surgical site infection (SSI) is a significant complication with literature for hemiarthroplasty infection stating rates as high as 7.3%. Therefore, the prevention of postoperative complications is likely to be one good way of reducing mortality in this group of patients.
Perioperative antibiotics are one proven means of reducing postoperative infection in patients undergoing hip arthroplasty for any indication. The current standard for cemented hip hemiarthroplasty is the use of parenteral antibiotics in combination with antibiotic loaded cement.
This will be multi centre, multi-surgeon, parallel, two arm, randomised controlled trial. This will be embedded in the World Hip Trauma Evaluation (WHITE) comprehensive cohort.
All adult patients 60 years of age and over presenting at the trial centres, who in the opinion of the treating surgeon require acute surgical treatment with a cemented hip hemiarthroplasty are eligible for inclusion.
The aim of this pragmatic randomised controlled trial is to determine the rate of deep infection in patients treated with either low dose single antibiotic loaded cement or high dose dual antibiotic loaded cement for the treatment of hip fracture with a hemi-arthroplasty.
This study is sponsored by the Northumbria Heathcare NHS Foundation Trust, and is funded by Heraeus Medical. The trial is managed by Oxford Trauma, at the University of Oxford.
20 February 2018 - Welcome to Morriston Hospital (Ian Pallister & team) who have opened for recruitment to the WHiTE 8 trial. We're looking forward to seeing your first recruit!
12 February 2018 - The February issue of the WHiTE 8 Newsletter is now available. Let us know if you have anything you'd like to see added to the newsletter (e.g. tips to share, issues you'd like help with, etc).
08 February 2018 - We've set up some teleconferences with sites to discuss common issues and to share good practice across our research sites. Stay tuned for an email inviting your team to join us at one of the scheduled teleconference sessions.
23 January 2018 - With a bit of delay, see the link included here for the January issue of the WHiTE 8 newsletter.
10 January 2018 - A warm New Year's welcome to Ipswich Hospital who have opened for recruitment to the WHiTE study today. We're happy to have Chris Roberts and his research staff join the WHiTE team.
24 Deember 2018 to 04 January 2019 - Our trial office will be closed during the holiday period, however we will still be monitoring our mailboxes, so if you have any urgent queries, please email the trial mailbox and mark the email as 'urgent' in the subject. Happy Holidays to all of our participating sites!