Welcome to the White8 trial website
BACKGROUND
Fragility hip fractures present a significant global challenge to patients, clinicians and healthcare systems. The global literature confirms an overall mortality risk in the range 10-40% in the first year with much of this attributed to post-operative complications.
Surgical site infection (SSI) is a significant complication with literature for hemiarthroplasty infection stating rates as high as 7.3%. Therefore, the prevention of postoperative complications is likely to be one good way of reducing mortality in this group of patients.
Perioperative antibiotics are one proven means of reducing postoperative infection in patients undergoing hip arthroplasty for any indication. The current standard for cemented hip hemiarthroplasty is the use of parenteral antibiotics in combination with antibiotic loaded cement.
TRIAL DESIGN
This will be multi centre, multi-surgeon, parallel, two arm, randomised controlled trial. This will be embedded in the World Hip Trauma Evaluation (WHITE) comprehensive cohort.
All adult patients 60 years of age and over presenting at the trial centres, who in the opinion of the treating surgeon require acute surgical treatment with a cemented hip hemiarthroplasty are eligible for inclusion.
AIM
The aim of this pragmatic randomised controlled trial is to determine the rate of deep infection in patients treated with either low dose single antibiotic loaded cement or high dose dual antibiotic loaded cement for the treatment of hip fracture with a hemi-arthroplasty.
This study is sponsored by the Northumbria Heathcare NHS Foundation Trust, and is funded by Heraeus Medical. The trial is managed by Oxford Trauma, at the University of Oxford.
29 July 2019 - We have now reached our 2000th participant recruited to the WHiTE 8 trial. The 2000th participant ID (W8-12000) was randomised by Royal Berkshire Hospital, however technically, this is not the 2000th participant as we have had several randomisation errors. The 2000th participant was actually W8-12010, who was randomised by Southmead Hospital. Regardless, it's been another busy day of recruits and we thank all teams for their efforts with consenting and recruiting participants to the study!
24 June 2019 - Welcome to Mr Teivendran and his team who have now opened for recruitment for the WHiTE 8 study.
06 June 2019 - Luton and Dunstable have now joined the WHiTE team, both for the Cohort and for WHiTE 8. Welcome to Mr Kalairajah and his team.
01 June 2019 - The June newsletter is ready for sites to read
15 May 2019 - We have now reached 1,500 participants recruited to the WHiTE 8 Study!
01 May 2019 - See the following link for the May Newsletter
24 April 2019 - Welcome to Ben Rogers and his team at Royal Sussex County Hospital who opened for recruitmet today.
01 April 2019 - The April Newsletter is now available for you to read
29 March 2019 - Queen Elizabeth Hospital are the latest team to open for recruitment for WHiTE 8. Welcome to Mr Mahmood and his team!
01 March 2019 - 1000 PATIENTS!! You have now helped us to recruit 1000 participants to the WHiTE 8 Copal trial. Southmead were the lucky site to recruit W8-11000. We are very grateful to all of you for your hard work with screening, consenting & recruiting patients to this study, and for your diligence with sending us the related documents and data. See here for the March Newsletter
20 February 2019 - Welcome to Morriston Hospital (Ian Pallister & team) who have opened for recruitment to the WHiTE 8 trial. We're looking forward to seeing your first recruit!
12 February 2019 - The February issue of the WHiTE 8 Newsletter is now available. Let us know if you have anything you'd like to see added to the newsletter (e.g. tips to share, issues you'd like help with, etc).
08 February 2019 - We've set up some teleconferences with sites to discuss common issues and to share good practice across our research sites. Stay tuned for an email inviting your team to join us at one of the scheduled teleconference sessions.
23 January 2019 - With a bit of delay, see the link included here for the January issue of the WHiTE 8 newsletter.
10 January 2019 - A warm New Year's welcome to Ipswich Hospital who have opened for recruitment to the WHiTE study today. We're happy to have Chris Roberts and his research staff join the WHiTE team.
24 Deember 2018 to 04 January 2019 - Our trial office will be closed during the holiday period, however we will still be monitoring our mailboxes, so if you have any urgent queries, please email the trial mailbox and mark the email as 'urgent' in the subject. Happy Holidays to all of our participating sites!
Key paper - The use of high-dose dual-impregnated antibiotic-laden cement with hemiarthroplasy... Bone Joint J. 2016 Nov; 98-B(11): 1534–1541.
